Table 3:

Predictors of ACRN, Cox regression analysis

		Univariable			Multivariable**
Variable	ACRN (%)	HR	95% CI	P value*	aHR	95% CI	P value*
Patients with ACRN, n (%)	41 (100)
Age at index colonoscopy	-	1.02	0.99 – 1.04	0.17
Male sex	27 (65.9)	1.77	0.93 – 3.38	0.08	1.96	0.99 – 3.88	0.06
USA cohort#	16 (39.0)	2.41	1.28 – 4.55	0.01	1.39	0.66 – 2.91	0.39
Presence of PIPs^	17 (41.5)	1.56	0.82 – 2.96	0.17	1.17	0.59 – 2.31	0.65
Primary sclerosing cholangitis	9 (22.0)	1.70	0.81 – 3.57	0.16	2.30	1.05 – 5.06	0.04
Dysplasia at/before index colonoscopy##	19 (46.3)	5.92	3.06 – 11.42	<0.0005	4.89	2.60 – 9.22	<0.0005
Mean histologic inflammation	-	2.40	1.63 – 3.53	<0.0005	2.11	1.34 – 3.34	<0.001
Disease duration at index colonoscopy	-	1.05	1.02 – 1.08	0.003	1.04	1.01 – 1.08	0.005
Cecum reached	-	0.11	0.01 – 0.85	0.03	0.09	0.01 – 0.68	0.02
Family history of Colorectal Cancer	5 (12.2)	2.32	0.91 – 5.91	0.08	1.94	0.73 – 5.15	0.18
Exposure to 5-Aminosalicylates	38 (92.7)	2.42	0.75 – 7.86	0.14
Crohn’s Disease^^	16 (39.0)	1.38	0.74 – 2.60	0.31
Adequate Bowel Preparation	-	1.25	0.27 – 5.69	0.78
Exposure to biologicals	7 (17.1)	1.05	0.46 – 2.37	0.91
Number of surveillance colonoscopies	-	0.92	0.78 – 1.10	0.36
Exposure to thiopurines	-	0.70	0.37 – 1.33	0.27
Extensive disease	33 (80.5)	0.56	0.26 – 1.22	0.15

^*Significant at P <0.05 level. ACRN: Advanced colorectal neoplasia. PIPs: Post-inflammatory polyps.

^#Reference category: Dutch cohort.

^{^}Analyzed as time-changing covariate.

^##Indefinite for dysplasia or low-grade dysplasia (patients with HGD excluded from outset).

^{^^}Reference category: Ulcerative colitis/IBD-unclassified.

^**Note:38 patients (1 ACRN) were excluded due to missing data.