Table 3.
Predictors of CRN, Cox regression analysis
| Univariable | Multivariable | ||||||
|---|---|---|---|---|---|---|---|
| Events n (%) |
HR | 95% CI | p-value | aHR | 95% CI | p-value | |
| CRN, n (%) | 46 (100) | ||||||
| Age | - | 1.03 | 1.01 – 1.05 | 0.003* | 1.02 | 0.99 – 1.04 | 0.18 |
| Male Sex | 23 (50) | 1.07 | 0.61 – 1.88 | 0.81 | - | - | - |
| IND1 | 14 (30) | 2.57 | 1.33 – 4.95 | 0.005* | 3.25 | 1.50 – 7.05 | 0.003* |
| Prior IND | 3 (7) | 0.89 | 0.27 – 2.92 | 0.85 | 0.64 | 0.18 – 2.22 | 0.48 |
| PSC | 15 (33) | 1.64 | 0.89 – 3.02 | 0.11 | 1.69 | 0.81 – 3.50 | 0.16 |
| Mean Histologic Inflammation | - | 1.09 | 0.79 – 1.51 | 0.59 | 1.13 | 0.77 – 1.65 | 0.53 |
| Disease duration | - | 1.02 | 1.00 – 1.05 | 0.07 | 1.02 | 0.99 – 1.06 | 0.21 |
| Crohn’s Disease2 | 16 (35) | 0.73 | 0.40 – 1.32 | 0.29 | - | - | - |
| Number of adequate surveillance colonoscopies | - | 1.11 | 0.97 – 1.27 | 0.12 | 1.08 | 0.93 – 1.24 | 0.33 |
| Extensive colitis | 35 (76) | 1.67 | 0.90 – 3.12 | 0.11 | 1.26 | 0.61 – 2.61 | 0.53 |
| Family history of CRC | 1 (2) | 0.46 | 0.06 – 3.38 | 0.45 | - | - | - |
| Exposure to biologicals | 16 (35) | 0.67 | 0.37 – 1.22 | 0.19 | - | - | - |
| Exposure to immunomodulators | 22 (48) | 0.55 | 0.31 – 0.97 | 0.04 | 0.64 | 0.34 – 1.21 | 0.17 |
| Exposure to 5-ASA | 39 (85) | 0.43 | 0.21 – 0.86 | 0.02 | 0.56 | 0.25 – 1.25 | 0.16 |
1) Entered as time-changing covariate 2) Reference category: UC/IBD-U 3) 7 patients were excluded due to missing values.
*
Significant at p<0.05.