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. 2020 Jun;9(3):670–681. doi: 10.21037/tlcr-19-401

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2020 Translational Lung Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Intratumoral genetic heterogeneity in form of structural variants. (A) Overlap of structural variants detected by whole-genome sequencing (upper) and optical mapping (lower) among PT, LNM and TPV. (B) Genes associated with tumorigenesis and progression affected by structural variants detected by whole-genome sequencing and optical mapping in PT, LNM and TPV. (C) Genes associated with prognosis of lung cancer affected by structural variants detected by whole-genome sequencing and optical mapping. (Red dotted line represents P value >0.05) (D) KEGG enrichment of genes only affected by metastases-specific structural variants. (Red dotted line represents adjusted P value >0.05). PT, primary tumor; LNM, lymph node metastases; TPV, tumor thrombus in pulmonary vein.