Table 2. Predictors of OS obtained from stepwise multivariate Cox regression analysis of selected variables in the PLCO Trial.
| Variables1 | Category | Frequency3 | HR (95% CI) | P |
|---|---|---|---|---|
| Age | Continuous | 1,162 | 1.03 (1.02–1.05) | <0.001 |
| Sex | Male | 688 | 1.00 | |
| Female | 474 | 0.80 (0.69–0.93) | 0.005 | |
| Smoking status | Never | 114 | 1.00 | |
| Former | 638 | 1.64 (1.25–2.16) | <0.001 | |
| Current | 410 | 1.65 (1.23–2.20) | 0.001 | |
| Histology | AD | 570 | 1.00 | |
| SC | 279 | 1.14 (0.94–1.37) | 0.185 | |
| others | 313 | 1.32 (1.11–1.57) | 0.001 | |
| Stage | I–IIIA | 646 | 1.00 | |
| IIIB–IV | 516 | 2.80 (2.31–3.40) | <0.001 | |
| Chemotherapy | No | 630 | 1.00 | |
| Yes | 532 | 0.58 (0.49–0.69) | <0.001 | |
| Radiotherapy | No | 752 | 1.00 | |
| Yes | 410 | 0.95 (0.81–1.12) | 0.553 | |
| Surgery | No | 628 | 1.00 | |
| Yes | 534 | 0.21 (0.16–0.27) | <0.001 | |
| PLCG2 rs96736822 | TT/TG/GG | 513/518/131 | 0.85 (0.77–0.95) | 0.003 |
| PLPP1 rs1156139852 | TT/TA/AA | 451/545/166 | 1.17 (1.06–1.30) | 0.003 |
1, stepwise analysis in the final model including age, sex, smoking status, tumor stage, histology, chemotherapy, radiotherapy, surgery, PC1, PC2, PC3, PC4 and two SNPs; 2, rs9673682 and rs115613985 in an additive genetic model. The leftmost genotype was used as the reference; 3, there were 23 samples with missing date and thus were excluded. OS, overall survival; PLCO, Prostate, Lung, Colorectal and Ovarian cancer screening trial; HR, hazards ratio; CI, confidence interval; AD, adenocarcinoma; SC, squamous cell carcinoma.