Table S4. Function prediction of the two validated SNPs associated with survival of NSCLC*.
| SNP | Gene | Chromosome | Source of genotype | RegDB1 | Haploreg v4.12 | ||||
|---|---|---|---|---|---|---|---|---|---|
| Enhancer histone marks | DNAse | Motifs changed | Selected eQTL hits | dbSNP function annotation | |||||
| rs9673682 T>G | PLCG2 | 16 | Imputed | 4 | 4 tissues | BRST, CRVX, SKIN | STAT | 7 hits | Intronic |
| rs115613985 T>A | PLPP1 | 5 | Imputed | 6 | 5 tissues | – | 9 altered motifs | – | Intronic |
*, both of the two SNPs had no function in the SNPinfo: https://snpinfo.niehs.nih.gov/snpinfo/snpfunc.html; 1, RegulomeDB: http://regulomedb.org/; 2, Haploreg: http://archive.broadinstitute.org/mammals/haploreg/haploreg.php. SNP, single-nucleotide polymorphism; NSCLC, non-small cell lung cancer.