Table 2. Molecular alterations detected in ctDNA upon progression to osimertinib treatment.
| Number of cases | Gene | Genomic alteration | Method |
|---|---|---|---|
| 3 | EGFR | p.C797S | dPCR |
| 3 | PIK3CA | p.E545A | NGS, dPCR |
| 1 | PIK3CA | p.E545K | NGS, dPCR |
| 1 | EGFR | p.A750P | NGS, dPCR |
| 1 | EGFR | p.S464L | NGS, dPCR |
| 1 | EGFR | Amplification | NGS |
ctDNA, circulating tumor DNA; EGFR, epidermal growth factor receptor; NGS, next-generation sequencing; dPCR, digital PCR.