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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Bone. 2020 May 21;137:115449. doi: 10.1016/j.bone.2020.115449

Table 3.

Ex vivo gene delivery for bone regeneration.

Vector Cell Gene Species Model Reference
Adenovirus Bone marrow-derived MSCs BMP2 Mouse Radius bone defect [56]
Electroporation Bone marrow-derived MSCs BMP2 or BMP9 Mouse Ectopic bone [57]
Electroporation Bone marrow and adipose-derived MSCs BMP2 or BMP6 Mouse Ectopic bone [18]
Electroporation Bone marrow-derived MSCs BMP6 Pig Vertebral bone defect [58]
Electroporation Adipose-derived MSCs BMP6 Rat Vertebral bone defect [59]
Lentivirus Umbilical cord blood -derived MSCs BMP2 Mouse Ectopic bone [60]
Lentivirus Bone marrow-derived MSCs (freshly - isolated or sub-cultured) BMP2 Rat Femoral bone defect [65]
Adenovirus Gingival fibroblasts BMP2 Rat Calvaria bone defect [61]
Adenovirus Periosteal cells BMP2 Rabbit Mandible bone defect [62]
Baculovirus Adipose-derived MSCs BMP-2 and miR-148b Mouse Calvaria bone defect [73]
Polyethylenimine (PEI) Bone marrow-derived MSCs miRNA-20a and siRNA against noggin Rat Calvaria bone defect [78]
Baculovirus Adipose-derived MSCs BMP2 and CRISPR interference against noggin Rat Calvaria bone defect [80]