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. Author manuscript; available in PMC: 2021 Jul 10.
Published in final edited form as: ACS Infect Dis. 2020 Jun 24;6(7):1976–1997. doi: 10.1021/acsinfecdis.0c00326

Figure 5.

Figure 5.

A) Concentration-response plot for NpsA inhibition by 5, 8 and 9: 3-hydroxyanthraniloyl-AMS 5 (circle), 3-hydroxybenzoyl-AMS 8 (square), anthraniloyl-AMS 9 (triangle). The curve represents the best non-linear fit to the Morrison equation. Data are average (±SD) of triplicate experiments. B) Representative ITC binding isotherm of binding 5 to NpsA. (Top) Data obtained by titration of 25 nM NpsA with 0.25 μM 5. (Bottom) The integrated curve showing experimental points and the best fit (−).