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Summary of characterization of all three inhibitors against purified NpsA.
| Cmpd | appKi, (nM) | KD (mM) | ΔH (kcal/mol) | TΔS (kcal/mol) | ΔG (kcal/mol) | n |
|---|---|---|---|---|---|---|
| 5 | (5.4 ± 0.8) × 101 | (2.93 ± 0.28) × 101 | (−1.61 ± 0.16) × 101 | −5.67 ± 0.21 | (1.04 ± 0.16) × 101 | 1.06 ± 0.03 |
| 8 | (2.3 ± 0.4) × 102 | (1.12 ± 0.68) × 102 | (−1.64 ± 0.29) × 101 | −6.92 ± 2.91 | 9.45 ± 0.23 | 0.94 ± 0.01 |
| 9 | (1.2 ± 0.1) × 103 | (4.85 ± 2.50) × 102 | (−1.09 ± 0.35) × 101 | −2.31 ± 0.47 | 8.59 ± 0.31 | 1.17 ± 0.02 |
