Figure 3.

Effect of time post-surgery on lubricin and hyaluronan concentrations in each post-traumatic osteoarthritis model. Observed means ± standard error of the means are plotted. Symbols (* = P<0.0001; ** = P<0.001; ^† = P<0.05) indicate significant differences from pre-surgery (day 0). Lubricin concentrations increased following carpal osteochondral fragmentation (A), talar cartilage impact (B), and trochlear ridge full-thickness cartilage defect creation (C). Hyaluronan depletion is shown following carpal osteochondral fragmentation (D), and talar cartilage impact (E); however, loss of hyaluronan was not detected following creation of full-thickness cartilage defects in the trochlear ridge (F).