Table 3.

Linear, least square regression models for synovial fluid parameters (lubricin and hyaluronic acid concentrations) in each post-traumatic osteoarthritis model: A. osteochondral fragmentation in the equine carpus; B. cartilage impact injury in the equine tarsus; C. full-thickness cartilage defect in the equine femoropatellar joint. Variations in samples size can be accounted for via exhaustion of banked synovial fluid samples at various time-points. Intercept omitted for clarity.

	A. Osteochondral fragmentation
	Lubricin (n=160)			HA (n=168)
Predictors	Estimate	Std. Error	P-value	Estimate	Std. Error	P-value
Day			0.001			<0.0001
0	−69.18	28.34		0.031	0.015
7	75.66	26.09		−0.080	0.015
14	50.04	27.40		−0.064	0.015
21	44.87	24.29		−0.054	0.014
28	30.89	24.31		−0.027	0.014
35	−18.66	23.51		−0.004	0.014
42	0.24	24.29		0.031	0.014
49	−23.39	23.51		0.052	0.014
56	−59.73	24.31		0.010	0.014
63	−46.37	23.51		0.006	0.014
R2 (Adj. R2)	0.52 (0.45)			0.68 (0.63)
	B. Cartilage impact
	Lubricin (n=106)			HA (n=108)
Predictors	Estimate	Std. Error	P-value	Estimate	Std. Error	P-value
Day			<0.0001			<0.0001
0	−81.48	25.07		0.15	0.01
4	75.69	25.58		−0.06	0.01
7	104.84	26.56		−0.08	0.01
14	112.59	29.97		−0.08	0.01
28	−27.25	29.12		−0.05	0.01
43	−72.43	27.28		−0.01	0.01
71	−37.74	31.73		0.04	0.01
TP (g/dl)	9.60	9.29	0.3	0.00	0.00	0.08
R2 (Adj. R2)	0.58 (0.51)			0.90 (0.88)
	C. Cartilage defect
	Lubricin (n=64)			HA (n=65)
Predictors	Estimate	Std. Error	P-value	Estimate	Std. Error	P-value
Day			0.03			0.6
0	−41.44	26.49		0.00	0.07
84	74.90	26.90		−0.06	0.07
R2 (Adj. R2)	0.49 (0.48)			0.45 (0.43)