Table 1.
Five cases of fetal death in women with COVID-19.
| Characteristics | Case 1 | Case 2 | Case 3 | Case 4 | Case 5 |
|---|---|---|---|---|---|
| Age, years | 32 | 35 | 40 | 24 | 30 |
| Parity | G1P0 | G2P1 | G2P0 | G1P0 | G3P0 |
| BMI category | Obese | Overweight | Obese | Overweight | Overweight |
| Diagnosis of COVID-19 (positive RT-PCR) | COVID day#4 | COVID day#6 | Asymptomatic | COVID day#1 | COVID day#7 |
| Diagnosis of fetal death | COVID day#14 | COVID day#6 | Asymptomatic | COVID day#22 | COVID day#11) |
| GA at fetal death, weeks | 28 3/7 | 21 1/7 | 38 3/7 | 23 4/7 | 30 6/7 |
| Birth weight | 1070 g | 329 g | 2895 g | 680 g | 1430 g |
| RT-PCR in placenta and AF | Placenta: positive AF: not performed |
Placenta: not performed AF: not performed |
Placenta: negative AF: Inconclusive |
Placenta: not performed AF: not performed |
Placenta: positive AF: positive |
| Placental and fetal histopathology | Intense acute villitis and intervillitis. Increased deposition of villous and intervillous fibrin. Acute chorioamnionitis. Findings suggestive of villitis of unknown etiology. |
Intense acute villitis and intervillitis. Increased deposition of villous and intervillous fibrin. Focal acute chorioamnionitis. Placental findings suggestive of ischemia and villitis. Fetus: Neutrophils in alveolar spaces. | Acute chorioamnionitis. Subchorionic thrombosis. Findings suggestive of ischemia and infection. | Acute chorioamnionitis. Acute deciduitis. Findings suggestive of ischemia and infection. |
Acute chorioamnionitis. Acute deciduitis. |
AF: Amniotic fluid. BMI: Body mass index. GA: Gestational age.