Table 3. Diagnostic value of PSAD, age and the combination for PI-RADS 3 index lesions of PZ.
| Risk factors | AUC | Decision to biopsy | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Avoid biopsy, % [n] | Missed csPCa, % [n] |
|---|---|---|---|---|---|---|---|---|
| PSAD | 0.728 | PSAD ≥0.15 | 80.0 | 38.64 | 22.9 | 89.5 | 35.2 [19] | 20.0 [2] |
| Age | 0.766 | Age >68 | 80.0 | 63.6 | 25.0 | 66.7 | 55.6 [30] | 20.0 [2] |
| Combination | 0.816 | PSAD ≥0.15 and age >68 | 70.0 | 75.2 | 38.9 | 83.3 | 66.7 [36] | 30.0 [3] |
| PSAD ≥0.15 or age >68 | 90.0 | 27.3 | 22.0 | 92.3 | 24.1 [13] | 10.0 [1] |
PSAD, prostate-specific antigen density; PI-RADS, Prostate Imaging Reporting and Data System; PZ, peripheral zone; AUC, area under the curve; PPV, positive predictive value; NPV, negative predictive value; csPCa, clinically significant prostate cancer.