Table 2. SNPs attaining statistical significance for interaction with smoking status in the BCPP cohort.
| Phenotype | rsID | BP | Locus | REF allele | EFF allele | MAF | β (cm) (SNP) | P (SNP) | β (cm) (never smokers) | P (never smokers) | β (cm) (smokers) | P (smokers) | P (SNP × smoking status)a | P (SNP × smoking intensity)b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tumor size (cm) | Not yet assigned | 38247577 | 14q21.1 | CTGG | C | 0.01 | 8.1 | 9.41E–14 | –1.6 | 1 | 7.1 | 1.93E–13 | 0.0008 | 0.07 |
| rs35225990 | 46117489 | 13q14.13 | C | T | 0.07 | 1.5 | 5.17E–09 | 7.9 | 8.54E–14 | 1.0 | 4.52E–05 | 0.005 | 0.37 | |
| rs188958632 | 38266174 | 14q21.1 | G | A | 0.01 | 2.8 | 1.02E–06 | 9.9 | 9.84E–05 | 2.6 | 6.98E–07 | 0.008 | 0.29 | |
| rs180910528 | 79821806 | 6q14.1 | A | C | 0.01 | 3.9 | 2.64E–11 | 9.9 | 8.44E–05 | 3.4 | 5.88E–09 | 0.02 | 0.33 | |
| rs74603364 | 79509518 | 6q14.1 | C | T | 0.02 | 2.5 | 1.88E–08 | 7.1 | 5.25E–05 | 2.3 | 1.42E–07 | 0.02 | 0.20 | |
| rs187040828 | 79802426 | 6q14.1 | T | C | 0.01 | 3.9 | 3.58E–11 | 9.3 | 0.0001 | 3.4 | 6.79E–09 | 0.02 | 0.33 | |
| rs144383242 | 79489625 | 6q14.1 | G | T | 0.01 | 3.5 | 5.74E–11 | 8.1 | 0.0004 | 3.0 | 6.55E–09 | 0.03 | 0.24 | |
| rs117587674 | 79432536 | 6q14.1 | G | A | 0.01 | 3.5 | 4.67E–11 | 8.1 | 0.0004 | 3.0 | 5.56E–09 | 0.03 | 0.24 | |
| rs113705641 | 5375733 | 3p26.1 | A | G | 0.02 | 9.5 | 2.68E–27 | –3.1 | 1 | 2.4 | 2.39E–06 | 0.03 | 0.95 | |
| rs2937268 | 66553607 | 1p31.3 | C | T | 0.04 | 2.6 | 3.28E–11 | 1.4 | 0.29 | 2.3 | 7.08E–11 | 0.04 | 0.06 |
a, Interaction with smoking status (never or ever smokers); b, interaction with smoking intensity (number of cigarettes smoked per day). Restricted to smokers only. SNP, single nucleotide polymorphism; BCPP, Bladder Cancer Prognosis Programme; rsID, SNP ID; BP, base pair; REF, reference; EFF, effect; MAF, minor allele frequency; cm, centimeters.