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. 2020 Jun;9(3):1314–1322. doi: 10.21037/tau.2020.03.18

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2020 Translational Andrology and Urology. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Association of miRNA expression and clinicopathological parameters in pRCC sera. (A) Normalized miR-21-5p and (B) miR-210-3p expression in healthy control sera, localized and advanced pRCC disease, divided into the respective participating centers (left plots) and subsequent cross-cohort comparison (right plots). (C) AUC curves regarding the diagnostic accuracy of normalized miR-210-3p (left plot), miR-21-5p (middle plot) expression and a combination of both (right plot) regarding localized and advanced pRCC. *, P<0.05; **, P<0.01; ***, P<0.001.