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Effects of EDTA on contact activation in whole blood versus plasma. Enzyme:serpin analysis on plasmas collected in various anticoagulants as indicated. All values shown are relative to pM complex concentration detected in citrated plasma. **P ≤ .01, ****P ≤ .0001. α1at, alpha‐1 antitrypsin; AT, antithrombin; C1, C1 esterase inhibitor; FIXa, activated factor IX; FXIa, activated factor XI; FXIIa, activated factor XII; PKa, kallikrein
