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Working model for Apolipoprotein E4 (ApoE4) contribution to Alzheimer’s disease (AD) development. Different stimuli can induce ApoE4 and ApoE3 overexpression, with E4 contribution to neurodegeneration in AD. ApoE4, undergoing to proteolytic cleavage, can generate different fragments which can contribute to mitochondrial dysfunction, cytoskeletal disorganization, neurofibrillary tangles and, consequently to neurodegeneration.
