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. 2020 May 29;12(6):593. doi: 10.3390/v12060593

Figure 8.

Figure 8

Pathological assessment of tissues of aerosol infected non-human primates. Lung (1a–1e, 20×), spleen-white pulp (2a–2e, 40×), spleen-red pulp (3a–3e, 40×), liver (4a–4e, 40×), adrenal gland (5a–5e, 40×), and heart (6a–6e, 20×). Tissues were from ● survivor on DPE 41 (all tissues), ■ D10:non-survivor (lung and heart) and ▼ D10:non-survivor.2 (liver, spleen tissues, and adrenal gland). Tissue sections embedded in paraffin were stained for LASV GP2 in non-survivor (IHC-GP: 1a–6a), H&E stain for non-survivor on DPE 10 (1b–6b), and H&E stain for survivor on DPE 41 (1c–6c). Detection of viral genomic RNA was performed using nucleic acid probe, targeting the polymerase gene with the L segment at sequence 466–1433, in non-survivors on DPE 10 (1d–6d) and absent in the survivor on DPE 41 (1e–6e) on far right column.