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. 2020 Jun 12;12(6):391. doi: 10.3390/toxins12060391

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Combined interaction between drugs and p-cresylsulfate (PCS) on OAT1-mediated fluorescein uptake. (A) Schematic representation of the co-incubation of fluorescein with variable concentrations of drugs and fixed concentration of PCS. (B) The drug alone (grey line) shows a concentration-dependent inhibition effect. During the co-incubation of cells with variable drug concentrations and a fixed concentration of PCS (125 µM, purple line), the concentration-dependent inhibition trend is maintained. All data are expressed as mean ± SD of four independent experiment. Curves were obtained after non-linear regression analysis. The reference value for the drug alone (grey line) is fluorescein without the drug (100%), while for the co-incubation with PCS (purple line) the reference value is fluorescein in the presence of PCS without the drug (46.7 ± 4.5%). Grey regions indicate the therapeutic window of the respective drug.