Table 1.

Inhibitory potencies of selected drugs on fluorescein uptake in ciPTEC-OAT1.

Drug	IC50 (µM) a	R Square b	Therapeutic Concentrations (µM) [44]
ACEIs
Captopril	2022 ± 465	0.5557	0.2–5
Enalaprilate	1853 ± 370	0.6753	0.04–0.4
Lisinopril	not available	0.1671	0.01–0.16
ARBs
Losartan	3.1 ± 0.7	0.8713	0.5–1.5
Valsartan	11.5 ± 3.5	0.9374	2–14
Diuretics
Furosemide	28.1 ± 9.1	0.9301	6–30
Statins
Pravastatin	13.8 ± 8.5	0.8757	0.08–0.3 [45]; 0.43 [46,47]
Simvastatin	21.3 ± 3.8	0.8613	0.006–0.014 [44]; 0.55 [46,47]
H2RA
Cimetidine	887.6 ± 198.4	0.7441	1–16

^a Data are expressed as mean ± SD. ^b Curves were obtained after non-linear regression analysis. Abbreviations: ACEIs = angiotensin-converting enzyme inhibitors; ARBs = angiotensin receptor blockers; H2RA = histamine H₂ receptor antagonists, IC₅₀ = half maximal inhibitory concentration.