Table 2.
OAT1-mediated fluorescein uptake: IC50 (µM) in the absence (−) and presence (+) of individual uremic toxins (IS, KA and PCS).
| Drug/Toxin | − | +IS 110 µM | +KA 1 µM | +PCS 125 µM |
|---|---|---|---|---|
| ARBs | ||||
| Losartan | 8.6 ± 2.5 | 13.9 ± 5.9 b | 28.2 ± 2.7 a | 15.97 ± 3.9 a |
| Valsartan | 11.5 ± 3.5 | 16.1 ± 3.6 b | 46.9 ± 4.6 a | 17.9 ± 3.8 b |
| Statins | ||||
| Pravastatin | 13.8 ± 8.35 | 40.9 ± 9.2 a | 243.0 ± 45.8 a | 19.1± 3.2 a |
| Simvastatin | 21.3 ± 3.8 | 71.8 ± 27.3 a | 28.4 ± 10.1 b | 32.8 ± 7.6 a |
| Diuretics | ||||
| Furosemide | 28.1 ± 9.1 | 44.7 ± 12.4 a | 24.8 ± 6.2 b | 60.2 ± 1.0 a |
a significant increase when compared with IC50 values of corresponding drug alone, b no significant change when compared with IC50 values of corresponding drug alone. Abbreviations: IS = indoxyl sulfate; KA = kynurenic acid; PCS = p-cresylsulfate; ARBs = angiotensin receptor blockers.