Table 2.
Phases | Events | |
---|---|---|
1st phase | Hemostasis | Vasoconstriction, platelet infiltration and aggregation into the wound site, and fibrin formation |
2nd phase | Inflammation | Increased blood flow (neutrophil, monocyte, and leucocyte infiltration) and activation of resident immune cells to release cytokines and chemokines |
3rd phase | Proliferation | Angiogenesis, collagen remodeling, granulation tissue formation, and epithelialization |
4th phase | Remodeling | Collagen remodeling, vascular maturation, and regression |