Table 3.

Role of neutrophils in the pathology caused by hRSV and hMPV.

Study Model	hRSV	hMPV
In vivo model	○NETosis and ROS production may contribute to lung damage. ○May stimulate excessive mucus production.	○The extreme amount of neutrophils in samples of bronchioli and alveolar spaces correlates with the damage caused in the lung. ○Lack of neutrophils aggravates the symptoms of the illness.
In vitro model	○Extensive IL-8-mediated neutrophil infiltration to the airways during the infection. ○No direct implication in virus clearance.	○Migrating neutrophils express higher levels of CD11b and myeloperoxidase, promoting considerable damage to the epithelial cell monolayer.