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. 2020 Jun 19;12(6):410. doi: 10.3390/toxins12060410

Figure 3.

Figure 3

Conservation analysis of the gene clusters between Cordyceps and other fungi involved in toxin production. (A) Comparative analysis of the biosynthetic gene clusters (BGCs) encoded in the genomes of the selected Cordycipitaceae fungi. NRPS, non-ribosomal peptide synthetase; PKS, polyketide synthase; TS, terpene synthase. (B) Conservation between the gene clusters of C. militaris and those of P. roqueforti involved in PR-toxin production. (C) Conservation between the gene clusters of the Cordycipitaceae fungi C. cicadae and A. lecanii and that of F. graminearum involved in the biosynthesis of trichothecenes. (D) Conservation between the gene clusters of C. militaris and C. cicadae and that of U. virens involved in the production of ustilaginoidins. The genes labeled in the same color within the panels (B–D) represent orthologous relationships. The compound(s) shown in the right of the panels (B–D) indicates the structures of the representative metabolites produced by the known BGCs in the related or reference fungal species.