Table 4.
Collected Variable | All Patients ARI./ILI | Patients positive | Patients HCoVs Positive | Negative for All Viruses Tested | ||||||||||||||||||||||
Influenza Virus A | Influenza Virus B | All HCoVs Positive Patients* | p-Value | Single HCoV | Co-Pathogen | p-Value | p-Value | |||||||||||||||||||
n | % | n | % | n | % | n | % | FluA/HCoV | FluB/HCoV | n | % | n | % | singleHCoV/ Copathogen | n | % | HCoV/ Negative | |||||||||
Number of HCoVs positive patients | 1389 | 100.0 | 328 | 23.6 | 212 | 15.3 | 105 | 7.6 | 82 | 78.1 | 23 | 21.9 | 561 | 40.4 | ||||||||||||
Age | Median Age (years) | 34 | 36 | 28.5 | 34 | / | / | 39.5 | 11.0 | / | 36.0 | / | ||||||||||||||
Mean Age (Min-Max) (years) | 34.96 (0.08–97.0) | 34.53 (0.08–89) | 31.02 (0.67–91) | 34.61 (0.08–90) | 37.43 (0.50–90.0) | 24.5 (0.08–80) | 36.73 (0.25–90) | |||||||||||||||||||
Age IQR (years) | 13–53 | 13–51 | 10–48 | 11–52 | 16.0–53.5 | 3.5–44.0 | 17.0–54.0 | |||||||||||||||||||
n | % | n | % | n | % | n | % | p-Value | n | % | p-Value | n | % | p-Value | n | % | ||||||||||
0–14 years | 378 | 27.2 | 88 | 26.8 | 73 | 34.4 | 30 | 28.6 | 0.00005 | 0.908 | 0.535 | 18 | 22.0 | 0.00137 | 12 | 52.2 | 0.00005 | 0.008 | 124 | 22.1 | 0.406 | |||||
15–29 years | 210 | 15.1 | 42 | 12.8 | 37 | 17.5 | 14 | 13.3 | 13 | 15.9 | 1 | 4.3 | 0.295 | 93 | 16.6 | |||||||||||
30–44 years | 303 | 21.8 | 84 | 25.6 | 42 | 19.8 | 21 | 20.0 | 17 | 20.7 | 4 | 17.4 | 1 | 135 | 24.1 | |||||||||||
45–59 years | 268 | 19.3 | 69 | 21.0 | 34 | 16.0 | 25 | 23.8 | 22 | 26.8 | 3 | 13.0 | 0.267 | 104 | 18.5 | |||||||||||
60–74 years | 149 | 10.7 | 32 | 9.8 | 16 | 7.5 | 10 | 9.5 | 8 | 9.8 | 2 | 8.7 | 1 | 73 | 13.0 | |||||||||||
≥ 75 | 81 | 5.8 | 13 | 4.0 | 10 | 4.7 | 5 | 4.8 | 4 | 4.9 | 1 | 4.3 | 1 | 32 | 5.7 | |||||||||||
Sex | Female | 758 | 54.6 | 184 | 56.1 | 110 | 51.9 | 51 | 48.6 | 0.782 | 0.216 | 0.633 | 44 | 53.7 | 0.435 | 7 | 30.4 | 0.0174 | 0.06 | 311 | 55.4 | 0.202 | ||||
Male | 631 | 45.4 | 144 | 43.9 | 102 | 48.1 | 54 | 51.4 | 38 | 46.3 | 16 | 69.6 | 250 | 44.6 | ||||||||||||
n | % | NA | n | % | NA | n | % | NA | n | % | NA | n | % | NA | n | % | NA | n | % | NA | ||||||
Symptoms | Fever | 1298 | 95.2 | 25 | 321 | 98.5 | 2 | 205 | 97.2 | 1 | 94 | 91.3 | 2 | 0.00131 | 0.0439 | 72 | 88.9 | 1 | 22 | 100.0 | 1 | 0.198 | 513 | 93.4 | 12 | 0.400 |
Cough | 1087 | 87.8 | 151 | 247 | 92.2 | 60 | 173 | 88.7 | 17 | 84 | 89.4 | 11 | 0.397 | 1 | 66 | 90.4 | 9 | 18 | 85.7 | 2 | 0.688 | 418 | 82.9 | 57 | 0.128 | |
Sore throat | 659 | 53.2 | 151 | 125 | 46.6 | 60 | 101 | 51.8 | 17 | 64 | 68.1 | 11 | 0.000465 | 0.011 | 55 | 75.3 | 9 | 9 | 42.9 | 2 | 0.006 | 267 | 53.0 | 57 | 0.0068 | |
Dyspnea | 241 | 19.5 | 151 | 49 | 14.9 | 0 | 31 | 14.6 | 0 | 32 | 30.5 | 0 | 0.000817 | 0.00152 | 29 | 35.4 | 0 | 3 | 13.0 | 0 | 0.04 | 91 | 16.2 | 0 | 0.000963 | |
Rhinorrhea | 932 | 75.3 | 151 | 206 | 76.9 | 60 | 150 | 76.9 | 17 | 83 | 88.3 | 11 | 0.017 | 0.0257 | 64 | 87.7 | 9 | 19 | 90.5 | 2 | 1 | 355 | 70.4 | 57 | 0.000201 | |
Myalgia | 666 | 69.0 | 424 | 123 | 70.7 | 154 | 120 | 74.1 | 50 | 52 | 70.3 | 31 | 1 | 0.533 | 41 | 71.9 | 25 | 11 | 64.7 | 6 | 0.561 | 288 | 71.5 | 158 | 0.889 | |
Headache | 863 | 69.7 | 151 | 194 | 72.4 | 60 | 147 | 75.4 | 17 | 73 | 77.7 | 11 | 0.343 | 0.769 | 59 | 80.8 | 9 | 14 | 66.7 | 2 | 0.233 | 346 | 68.7 | 57 | 0.0866 | |
Malaise | 85 | 12.0 | 681 | 26 | 12.7 | 124 | 13 | 14.3 | 121 | 3 | 3.2 | 11 | 0.0104 | 0.00844 | 2 | 2.7 | 9 | 1 | 4.8 | 2 | 0.536 | 36 | 14.9 | 319 | 0.002 | |
Conjunctivitis | 345 | 24.8 | 0 | 67 | 20.4 | 0 | 59 | 27.8 | 0 | 32 | 30.5 | 0 | 0.0446 | 0.692 | 24 | 29.3 | 0 | 8 | 34.8 | 0 | 0.616 | 141 | 25.1 | 0 | 0.275 | |
Vomiting | 151 | 10.9 | 0 | 32 | 9.8 | 0 | 20 | 9.4 | 0 | 15 | 14.3 | 0 | 0.208 | 0.252 | 12 | 14.6 | 0 | 3 | 13.0 | 0 | 1 | 66 | 11.8 | 0 | 0.514 | |
Diarrhea | 154 | 11.1 | 0 | 23 | 7.0 | 0 | 23 | 10.8 | 0 | 10 | 9.5 | 0 | 0.401 | 0.845 | 9 | 11.0 | 0 | 1 | 4.3 | 0 | 0.442 | 68 | 12.1 | 0 | 0.512 | |
Other symptoms | 184 | 21.0 | 512 | 44 | 16.2 | 56 | 21 | 18.3 | 97 | 18 | 26.9 | 38 | 0.0521 | 0.192 | 15 | 30.6 | 33 | 3 | 16.7 | 5 | 0.757 | 82 | 25.0 | 233 | 0.759 | |
Anormal lung auscultation | 88 | 26.3 | 1055 | 24 | 25.3 | 233 | 8 | 17.0 | 165 | 8 | 38.1 | 84 | 0.282 | 0.0709 | 6 | 46.2 | 69 | 2 | 25.0 | 15 | 0.4 | 34 | 27.2 | 436 | 0.309 | |
Other variables | Risk factors | 321 | 23.5 | 22 | 59 | 18.3 | 6 | 41 | 19.4 | 1 | 16 | 15.2 | 0 | 0.555 | 0.4 | 13 | 15.9 | 0 | 3 | 13.0 | 0 | 1 | 145 | 26.4 | 11 | 0.0182 |
Oseltamivir | 241 | 18.0 | 49 | 88 | 27.7 | 10 | 29 | 14.0 | 5 | 14 | 13.6 | 2 | 0.00348 | 1 | 12 | 15.0 | 2 | 2 | 8.7 | 0 | 0.73 | 88 | 16.4 | 26 | 0.558 | |
Antibiotics | 173 | 13.3 | 86 | 43 | 14.2 | 25 | 18 | 8.8 | 7 | 10 | 9.9 | 4 | 0.31 | 0.833 | 7 | 8.9 | 3 | 3 | 13.6 | 1 | 0.45 | 73 | 14.1 | 43 | 0.338 | |
Hospitalization | 39 | 2.9 | 32 | 12 | 3.8 | 10 | 7 | 3.4 | 5 | 2 | 1.9 | 0 | 0.532 | 0.7 | 2 | 2.4 | 0 | 0 | 0.0 | 0 | 1 | 15 | 2.7 | 10 | 1 |
* Overall HCoV infections also include strains without species determination (N = 20).