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. 2020 Jun 25;12(6):419. doi: 10.3390/toxins12060419

Figure 2.

Figure 2

DAS-induced emetic effect corresponds to elevation of plasma peptide YY (PYY) and 5-HT, following IP exposure in mink. Data are mean ± SEM (n = 5/group). (A) Mean cumulative emetic events in mink following IP exposure to DAS. Kinetics of DAS-induced plasma (B) PYY and (C) 5-HT elevation. Relationship between emetic events and (D) PYY or (E) 5-HT levels at 60 min. Two-way ANOVA using the Holm–Sidak was used to analyze significant differences in mean cumulative emetic events and kinetics of plasma PYY and 5-HT in mink. Symbols: * indicates a statistically significant difference in mean cumulative emetic events and plasma PYY or 5-HT concentration, relative to the control at specific time point (p < 0.05) and € indicates a statistically significant difference in mean cumulative emetic events relative to the 0 min time point (p < 0.05). The Spearman rank-order correlation coefficient was used for correlation between emetic events and hormone levels (p < 0.05).