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. 2020 Jun 25;12(6):419. doi: 10.3390/toxins12060419

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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NPY2 receptor inhibitor JNJ-31020028 diminished emetic episodes induced by (A) PYY, (B) DAS following IP exposure, (C) DAS following oral exposure. Serotonin 3 receptor inhibitor granisetron abolished emetic episodes induced by (D) 5-HT, (E) DAS following IP exposure, (F) DAS following oral exposure. Emetic response comprises retching (black) and vomiting (gray) episodes. ND = not detected. Data represent mean ± SEM (n = 5/group). A one-way ANOVA using Holm–Sidak was used to assess significant differences between treatments and the respective controls. Symbols: * indicates statistically significant differences in emetic episodes (p < 0.05).