Table 1.
Comparison of emetogenic potentials upon intraperitoneal injection (IP) and oral exposure to diacetoxyscirpenol (DAS).
| Exposure Route | Dose (mg/kg bw) | Incidence (Responding/Tested) | Latency (min) A,B | Duration (min) A,B | Retch (Times) | Vomit (Times) | Total (Times) |
|---|---|---|---|---|---|---|---|
| IP | 0 | 0/5 | - | - | 0 ± 0 | 0 ± 0 | 0 ± 0 |
| 0.05 | 0/5 | - | - | 0 ± 0 | 0 ± 0 | 0 ± 0 | |
| 0.1 | 0/5 | - | - | 0 ± 0 | 0 ± 0 | 0 ± 0 | |
| 0.25 | 1/5 | 42 ± 0 a | 3 ± 0 a | 7 ± 7 | 2 ± 2 | 9 ± 9 | |
| 0.5* | 5/5 | 27 ± 4 a | 120 ± 13 b | 122 ± 11 | 15 ± 8 | 137 ± 19 | |
| 1* | 5/5 | 18 ± 5 a | 189 ± 19 b | 181 ± 31 | 25 ± 11 | 206 ± 42 | |
| Oral | 0 | 0/5 | - | - | 0 ± 0 | 0 ± 0 | 0 ± 0 |
| 0.01 | 0/5 | - | - | 0 ± 0 | 0 ± 0 | 0 ± 0 | |
| 0.025 | 0/5 | - | - | 0 ± 0 | 0 ± 0 | 0 ± 0 | |
| 0.05 | 0/5 | - | - | 0 ± 0 | 0 ± 0 | 0 ± 0 | |
| 0.1* | 4/5 | 29 ± 5 a | 97 ± 11 a | 87 ± 9 | 12 ± 4 | 99 ± 13 | |
| 0.25* | 5/5 | 20 ± 2 a | 141 ± 23 a | 153 ± 16 | 19 ± 11 | 172 ± 27 |
A Average of positive responders only. B If animals did not elicit emetic episodes, latency and duration are displayed as “-”. C Average of both non-responders and responders. Data are mean ± SEM. * indicate significant differences at p < 0.05 for incidence, retch, vomit and total emetic episodes. Different letters within a column indicate significant differences at p < 0.05.