Table 1.
Dysregulated miRNAs in breast cancer with extremely low or high basal abundance in BM. The inferential expression changes in early breast cancer (BC) are analyzed according to reports and basal abundance data from miRNA sequencing.
| miRNA name | miRNA sequence | Normalized reads | Inferential expression in early BC | |||
|---|---|---|---|---|---|---|
| cfRNA4 | cfRNA3 | cellRNA3 | cellRNA4 | |||
| hsa-miR-25-5p_R+2 | AGGCGGAGACTTGGGCAATTGCT | 35 | 42 | 28 | 43 | Upregulated |
| hsa-miR-34a-3p_R+1 | CAATCAGCAAGTATACTGCCCTT | 0 | 0 | 0 | 8 | Upregulated |
| hsa-miR-92a-2-5p | GGGTGGGGATTTGTTGCATTAC | 7 | 0 | 0 | 0 | Upregulated |
| hsa-miR-103a-2-5p | AGCTTCTTTACAGTGCTGCCTTG | 36 | 7 | 53 | 43 | Upregulated |
| hsa-miR-125b-1-3p | ACGGGTTAGGCTCTTGGGAGCT | 10 | 25 | 10 | 10 | Upregulated |
| hsa-miR-133a-3p_L-1R+1 | TTGGTCCCCTTCAACCAGCTGT | 8 | 4 | 7 | 2 | Upregulated |
| hsa-miR-155-3p | CTCCTACATATTAGCATTAACA | 0 | 0 | 5 | 4 | Upregulated |
| hsa-miR-191-3p_R-3 | GCTGCGCTTGGATTTCGTC | 30 | 14 | 7 | 0 | Upregulated |
| hsa-miR-192-3p_R+1 | CTGCCAATTCCATAGGTCACAGT | 0 | 0 | 0 | 4 | Upregulated |
| hsa-miR-195-3p_R-2 | CCAATATTGGCTGTGCTGCT | 50 | 42 | 43 | 40 | Upregulated |
| hsa-miR-199a-5p_R-1 | CCCAGTGTTCAGACTACCTGTT | 22 | 23 | 20 | 19 | Upregulated |
| hsa-miR-200c-5p | CGTCTTACCCAGCAGTGTTTGG | 18 | 6 | 65 | 25 | Upregulated |
| hsa-miR-202 | AGAGGTATAGCGCATGGGAA | 0 | 0 | 0 | 0 | Upregulated |
| hsa-miR-215-5p_R+1 | ATGACCTATGAATTGACAGACA | 0 | 0 | 18 | 26 | Upregulated |
| hsa-mir-222-p5 | AAGGTGTAGGTACCCTCAAT | 0 | 0 | 8 | 16 | Upregulated |
| hsa-miR-299-5p | TGGTTTACCGTCCCACATACAT | 0 | 0 | 0 | 0 | Upregulated |
| hsa-miR-373 | GAAGTGCTTCGATTTTGGGGTGT | 0 | 0 | 0 | 0 | Upregulated |
| hsa-miR-375-5p | GCGACGAGCCCCTCGCACAAACC | 19 | 12 | 0 | 0 | Upregulated |
| hsa-miR-376c | AACATAGAGGAAATTCCACGT | 0 | 0 | 0 | 0 | Upregulated |
| hsa-miR-382-5p | GAAGTTGTTCGTGGTGGATTCG | 17 | 0 | 0 | 10 | Upregulated |
| hsa-miR-382-3p_R+1 | AATCATTCACGGACAACACTTT | 0 | 0 | 0 | 4 | Upregulated |
| hsa-miR-409-5p_R-1 | AGGTTACCCGAGCAACTTTGCA | 14 | 0 | 0 | 23 | Upregulated |
| hsa-miR-409-3p_L+1 | CGAATGTTGCTCGGTGAACCCCT | 0 | 0 | 0 | 6 | Upregulated |
| hsa-miR-523-3p_L-1R-2 | AACGCGCTTCCCTATAGAGG | 11 | 19 | 8 | 0 | Upregulated |
| hsa-miR-526b-5p_R-1 | CTCTTGAGGGAAGCACTTTCTG | 7 | 25 | 32 | 14 | Upregulated |
| hsa-miR-625-5p_R-1 | AGGGGGAAAGTTCTATAGTC | 7 | 0 | 15 | 12 | Upregulated |
| hsa-let-7a-5p | TGAGGTAGTAGGTTGTATAGTT | 69874 | 57909 | 83431 | 129086 | Downregulated |
| hsa-let-7b-5p | TGAGGTAGTAGGTTGTGTGGTT | 82701 | 116853 | 81208 | 48587 | Downregulated |
| hsa-miR-30a-5p | TGTAAACATCCTCGACTGGAAG | 143946 | 97103 | 178925 | 183651 | Downregulated |
| hsa-miR-30b-5p | TGTAAACATCCTACACTCAGCT | 383303 | 264659 | 372314 | 346935 | Downregulated |
| hsa-miR-141-3p_R-1 | TAACACTGTCTGGTAAAGATG | 45058 | 66296 | 119600 | 65598 | Downregulated |
| hsa-miR-148a-3p | TCAGTGCACTACAGAACTTTGT | 386987 | 588485 | 918411 | 876058 | Downregulated |
| hsa-miR-148b-3p_R-1 | TCAGTGCATCACAGAACTTTG | 20149 | 21809 | 40891 | 61755 | Downregulated |
| hsa-miR-200c-3p | TAATACTGCCGGGTAATGATGGA | 764438 | 473643 | 254207 | 253470 | Downregulated |
| hsa-miR-200b-3p | TAATACTGCCTGGTAATGATGA | 354432 | 251845 | 266377 | 258231 | Downregulated |
| hsa-miR-200a-3p_R+1 | TAACACTGTCTGGTAACGATGTT | 345502 | 350091 | 385973 | 393857 | Downregulated |
| hsa-miR-335-5p_R-2 | TCAAGAGCAATAACGAAAAAT | 27462 | 21489 | 35648 | 31513 | Downregulated |
| hsa-miR-375-3p | TTTGTTCGTTCGGCTCGCGTGA | 170762 | 305772 | 53533 | 42830 | Downregulated |