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. Author manuscript; available in PMC: 2020 Jul 12.
Published in final edited form as: Neuron. 2017 Feb 2;93(4):822–839.e6. doi: 10.1016/j.neuron.2017.01.008

Figure 6. Laminar Organization and DOR/MOR Contribution to Enkephalinergic Presynaptic Inhibition of C- and A-fibers.

Figure 6.

(A) Example traces showing that the MOR antagonist CTOP (1 μM) reversed the light-induced enkephalinergic presynaptic inhibition of C fibers in lamina I/IIo, whereas the DOR antagonist Tipp-psi (1 μM) reversed presynaptic inhibition of A-fibers in lamina IIi/III.

(B) Quantification of (A) indicating the effect of CTOP and Tipp-psi on the light-induced increase in PPR 1,000 ms after light stimulation (Kruskal-Wallis test, *p < 0.05; **p < 0.01).

(C) Pie charts indicating the proportions of neurons in which light induced a significant increase in PPR (i.e., presynaptically inhibited) in laminae I/IIo and IIi/III and for C- and A-fibers (n = 26 neurons for lamina I/IIo and 18 for lamina IIi/III).

All bar graphs represent mean ± SEM.