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. Author manuscript; available in PMC: 2020 Nov 14.
Published in final edited form as: J Med Chem. 2019 Oct 21;62(21):9471–9487. doi: 10.1021/acs.jmedchem.9b00846

Figure 4. The cell growth inhibition activity of MG-277 does not require binding to MDM2.

Figure 4.

(A-C) Structures of MC-215, MC-216 and MC-217, three control analogues of MG-277 formed by removal of fluorine and/or one or two chlorine atoms from the MI-2103 portion of MG-277. (D-E) Cell growth inhibitory activity of MG-277, MC-215, MC-216 and MC-217 in RS4;11 (D) and RS4;11/IRMI-2 (E) cell lines. (F) Binding affinity of the three analogues of MG-277 with MDM2 protein was determined by an FP assay.