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Key points in the of the development of SPRMs (timeline) and current clinical significance. Mifepristone and ulipristal acetate are the only SPRMs in current clinical use. The use of Asoprisnil was halted due to concerns regarding endometrial changes (Guo & Groothuis 2018, Lewis et al. 2018). Telapristone studies were halted due to liver toxicity concerns (Lewis et al. 2018).
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