Figure 6.

Subbasal nerves detected by IVCM. a) Subbasal nerves in a normal indiviual; b) Decreased main nerve density (pink traces) and decreased nerve branching (blue tracing) in herpes simplex keratitis; c) Absence of subbasal nerve plexus in neurotrophic keratitis secondary to herpes simplex keratitis; d) Increased nerve tortuosity in dry eye disease (two semicircles on the same nerve branch shows most representative areas); e) Increased beading in a patient with neuropathic corneal pain (most representative beading areas are bordered by blue stars); e, f) Hyperreflective abnormal bulging of corneal nerve ending, microneuromas in patient with neuropathic corneal pain (green arrow heads).