Table 1.

Summary of outcomes.

Parameter	Index
(THF + allo-THF + THE + α-cortol + β-cortol + α-cortolone + β-cortolone)/creatinine	Sum of cortisol metabolites (cortisol metabolite excretion rate)
allo-THF/F	5α-reductase activity
THF/F	5β-reductase activity (a)
THE/E	5β-reductase activity (b)
F/E	11β-HSD type 2 activity
(THF + allo-THF)/THE	Balance of 11β-HSD activities
6β-OH cortisol/F	Cytochrome P450 3A4 activity

E, cortisone; F, cortisol; HSD, hydroxysteroid dehydrogenase; THE, tetrahydrocortisone; THF, tetrahydrocortisol.