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. Author manuscript; available in PMC: 2020 Jul 12.
Published in final edited form as: J Med Chem. 2020 May 26;63(11):6179–6202. doi: 10.1021/acs.jmedchem.0c00539

Figure 2.

Figure 2.

Bioluminescent and real-time in vivo imaging (IVIS) of parasite load in mice with and without acridone treatment. Mice were inoculated with 10000 luciferase-expressing P. berghei sporozoite intravenously (i.v.) on day 0 and oral doses of acridones were administered on day −1, day 0, and day 1. The bioluminescent level represents the parasite burden over the body surface area at 24, 48, and 72 h time points.