Table 5.

In Vivo Blood-Stage Antimalarial Efficacy against P. yoelii in Mice

compd	blood-stage efficacy vs. P. yoelii (4 days)
	ED50 (mg/kg/d)	ED90 (mg/kg/d)
T31	1.0	1.6
18a	0.52	0.82
19	1.8	1.9
21	4.5	6.8
20b	1.8	3.6
22c,d	0.18	0.32
23	5.0	9.8
24	0.55	0.86
25	3.7	6.3
26c	0.045	0.098
27b	2.1	7.2
28	>30	>30
29b,c	0.28	0.32
30	3.6	12
31	>30	>30
32	23	>30
33	5.4	8.9
34	2.8	7.5
35	>30	>30
36	>30	>30
37	1.8	14
38	0.75	3.9
39	1.3	7.3
40	0.16	3.6
41	>30	>30
42	>30	>30
43	0.23	9.8
44	0.23	0.79
45	0.96	2.2
46	>30	>30
47	1.1	2.3
48	4.1	7.4
49	3.7	6.7
50	6.8	>30
51	6.1	>30
52	>30	>30
53	10	19
54	27	>30
55	15	28
56	17	32
57	9.2	14.7
58	8.9	16
68	1.6	1.8
69	0.30	1.0
70	>30	>30
73	4.6	6.6
74	3.9	5.8
77	5.4	6.9
86	7.2	18
87	0.34	0.42
88c	0.36	0.45
89	0.28	7.7
90	0.17	0.63
91	0.15	0.56
92	0.38	0.47
93	8.0	15
99	6.1	12
100	2.8	13
101	>10	>10
102	>10	>10
107	0.15	1.5
108	<5.0	<5.0
109	9.5	16
CQ	1.5	3.3

^acurative at 5 mg/kg/d;

^bcurative at 30 mg/kg/d;

^ccurative at 10 mg/kg/d;

^dcurative at 3.0 mg/kg/d.