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. Author manuscript; available in PMC: 2020 Jul 12.
Published in final edited form as: J Med Chem. 2020 May 26;63(11):6179–6202. doi: 10.1021/acs.jmedchem.0c00539

Table 7.

In Vitro Cardiotoxicity of Second-Generation Acridones

compd hERG (% inhibition at 10 μM)
T31 57
18 13
19 13
20 23
21 28
22 17
24 24
25 18
26 5.7
27 23
28 16
29 15
31 14
32 13
34 16
35 13
37 22
38 14
39 17
40 14
41 9.2
42 22
43 15
44 20
46 23
49 15
50 22
51 17
52 31
58 21
68 25
69 9.9
70 15
72 17
73 15
75 12
76 13
77 13
78 12
79 24
80 10
CQ 39