Table 3. Effect of supplementation of zinc, glutamine, fiber, and prebiotics on fecal calprotectin, α1AT.
| Marker | Test formula (n=72) | Standard formula (n=72) | p-value | |
|---|---|---|---|---|
| Calprotectin | ||||
| V0 (mg/kg) | 197.9 (38.1–798.5) | 248.8 (31.0–805.8) | p=0.897∥ | |
| V6 (mg/kg) | 99.2 (20.1–479.4) | 125.6 (15.9–358.0) | p=0.102∥ | |
| V10 (mg/kg) | 148.3 (26.9–412.8) | 173.2 (31.4–808.5) | p=0.169∥ | |
| p (0-6)* | p<0.001 | p<0.001 | p (0-6)‡=0.29 | |
| p (0-10)† | p=0.002 | p=0.12 | p (0-10)§=0.33 | |
| α1AT mg/dL | ||||
| V0 (mg/dL) | 28.3 (6.48–190.13) | 32.6 (3.4–237.1) | p=0.441∥ | |
| V6 (mg/dL) | 13.3 (1.13–114.14) | 14.4 (1.0–59.5) | p=0.790∥ | |
| V10 (mg/dL) | 21.1 (2.46–63.32) | 25.0 (3.1–51.6) | p=0.085∥ | |
| p (0-6)* | p<0.001 | p<0.001 | p (0-6)=0.39¶ | |
| p (0-10)† | p<0.001 | p<0.001 | p (0-10)=0.97¶ | |
Values are presented as median (range).
α1AT: alfa-1-antitrypsin, V0: month-0, V6: month-6, V10: month-10.
Results in median with confidence of 95%; p-value shows interaction among groups and the difference of laboratory results between month-0 and month-10.
*Significance between month-0 and month-6 in each group. †Significance between month-0 and month-10 in each group. ‡Significance between the changes of month-0 and month-6 between trial group and placebo group. §Significance between the changes of month-0 and month-10 between trial group and placebo group. ∥Wilcoxon test, ¶Mann–Whitney test.