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Aflibercept-loaded microsphere thermo-responsive hydrogel DDS (aflibercept-DDS) is visible in the vitreous of a 4-year-old male rhesus macaque at 2 months postinjection. A representative image shows aflibercept-DDS (white arrows) that was delivered by IVT injection in the superotemporal anterior vitreous. The aflibercept-DDS was visible in the vitreous for 6 months postinjection.
