Figure 1.

TSLPR deficiency decreased Alternaria extract (Alt‐Ext)‐induced type‐2 airway inflammation. A, WT and TSLPR^−/− mice were challenged with Alt‐Ext intranasally for 4 consecutive days. Bronchoalveolar lavage fluid (BALF) and lung were harvested 24 h after the last Alt‐Ext‐challenge. Whole lungs for histological mucus detection were harvested 48 h after the last Alt‐Ext‐challenge. B, Cell differentials in BALF. C, The number and percentage of lung group 2 innate lymphoid cells (ILC2) expressing IL‐5 and IL‐13. D, The protein level of IL‐4, IL‐5, and IL‐13 in the lung homogenates. E, Representative sections and mucus score as determined by periodic acid‐Schiff (PAS) staining. The data are a combination of 2 independent experiments and shown as mean ± SD (n = 4‐9). *P < .05