Table 1.
Demographics and Ocular Characteristics of Study Population
| Healthy (N=14, Eye=23) | Pre-perimetric Glaucoma (N=19, Eye=36) | Glaucoma (N=61, Eye=80) | P value | |
|---|---|---|---|---|
| Sex (Male / Female) | 4 / 10 | 8 / 11 | 33/ 28 | 0.205 |
| Race | ||||
| African American | 7 (50.0%) | 2 (10.5%) | 15 (24.6%) | 0.0551 |
| Caucasian | 4 (28.6%) | 15 (78.9%) | 35 (57.4%) | |
| Other | 3 (21.4%) | 2 (10.5%) | 11 (18.0%) | |
| Self-reported history of Diabetes | 0 (0.0%) | 1 (5.3%) | 7 (11.5%) | 0.562 |
| Self-reported history of Hypertension | 7 (50.0%) | 10 (52.6%) | 33 (54.1%) | 1.000 |
| Systolic Blood Pressure (mmHg) | 118.6 (112.0, 125.3) | 128.5 (117.4, 139.5) | 127.0 (122.6, 131.4) | 0.0362 |
| Diastolic Blood Pressure (mmHg) | 78.6 (72.7, 84.5) | 82.9 (77.5, 88.3) | 79.9 (76.4, 83.4) | 0.690 |
| Mean Arterial Pressure (mmHg) | 91.9 (86.3, 97.6) | 98.1 (91.2, 105.0) | 95.6 (92.2, 99.0) | 0.250 |
| Baseline Age | 52.2 (46.4, 57.9) | 68.2 (65.8, 70.6) | 67.9 (65.5, 70.3) | <0.0011, 2 |
| Axial Length (mm) | 23.7 (23.1, 24.4) | 24.4 (24.1, 24.7) | 24.5 (24.2, 24.8) | 0.0472 |
| Central Corneal Thickness (μm) | 546.5 (526.5, 566.6) | 539.9 (530.6, 549.3) | 547.5 (538.9, 556.2) | 0.0383 |
| Mean IOP during follow-up (mmHg) | 13.8 (12.0, 15.6) | 16.3 (15.2, 17.4) | 15.3 (14.4, 16.1) | 0.0451 |
| Baseline Mean Deviation (dB) | 0.18 (−1.40, 1.76) | −0.81 (−1.96, 0.35) | −4.19 (−4.99, −3.39) | <0.0012, 3 |
| Glaucoma Severity | ||||
| Mild | 61 (76.2%) | |||
| Moderate | 14 (17.5%) | |||
| Advanced | 5 (6.2%) | |||
| Baseline PSD (dB) | 1.68 (0.27, 3.10) | 2.06 (1.04, 3.08) | 5.40 (4.69, 6.11) | <0.0012, 3 |
| Baseline cpRNFL thickness (μm) | 99.1 (91.7, 106.5) | 83.3 (78.4, 88.1) | 74.9 (71.4, 78.5) | <0.0011, 2, 3 |
| Baseline Vessel Density (%) | ||||
| Whole Image | 48.4 (46.4, 50.5) | 45.4 (44.0, 46.8) | 43.8 (42.8, 44.8) | <0.0011, 2 |
| Perifoveal | 51.0 (48.9, 53.1) | 48.0 (46.5, 49.5) | 46.5 (45.5, 47.6) | 0.0011, 2 |
| Baseline GCC Thickness (μm) | ||||
| Whole Image | 104.4 (98.7, 110.0) | 95.9 (92.1, 99.6) | 88.8 (86.1, 91.6) | <0.0011, 2, 3 |
| Perifoveal | 109.4 (103.3, 115.4) | 101.2 (97.1, 105.3) | 93.3 (90.3, 96.2) | <0.0011, 2, 3 |
IOP = intraocular pressure; PSD = pattern standard deviation; cpRNFL = circumpapillary retinal nerve fiber layer; GCC = ganglion cell complex.
Continuous data are shown as mean (95% confidence interval). Values with statistical significance are shown in bold.
1
Healthy vs. Pre-perimetric Glaucoma Significant;
2
Healthy vs. Glaucoma Significant;
3
Pre-perimetric Glaucoma vs. Glaucoma Significant.