Table 4.

Results of Univariable Models Assessing the Effect of Each Putative Predictive Factor on Change of Whole Image Ganglion Cell Complex Thickness and Vessel Density Over Time

	Healthy		Pre-perimetric Glaucoma		POAG
GCC Thickness	Estimate (95% CI)	P Value	Estimate (95% CI)	P Value	Estimate (95% CI)	P Value
Baseline Age, per year older	−0.01 (−0.04, 0.01)	0.318	0.02 (−0.01,0.05)	0.257	0.01 (−0.01,0.02)	0.478
Race: Caucasian	−0.06 (−0.63, 0.50)	0.829	−0.29 (−1.12, 0.53)	0.491	0.07 (−0.32, 0.46)	0.718
Gender: Male	−0.36 (−0.91,0.20)	0.226	0.49 (−0.20, 1.18)	0.172	−0.14 (−0.52, 0.25)	0.496
Mean IOP, per 1mmHg higher	−0.10 (−0.20,−0.01)	0.043	−0.16 (−0.22,−0.09)	<0.001	−0.08 (−0.15, −0.02)	0.018
MD, per 1dB better	−0.11 (−0.34,0.12)	0.356	0.07 (−0.11,0.26)	0.453	0.01 (−0.03, 0.06)	0.586
Overall QI, per 1 unit higher	0.04 (−0.26, 0.35)	0.778	−0.03 (−0.23, 0.17)	0.765	−0.12 (−0.27,0.03)	0.105
Vessel Density	Estimate (95% CI)	P Value	Estimate (95% CI)	P Value	Estimate (95% CI)	P Value
Baseline Age, per year older	−0.00 (−0.03, 0.03)	0.807	−0.01 (−0.04, 0.02)	0.662	−0.01 (−0.03,0.01)	0.416
Race: Caucasian	−0.23 (−0.91,0.46)	0.518	0.08 (−0.76, 0.93)	0.846	−0.32 (−0.82, 0.18)	0.213
Gender: Male	−0.09 (−0.81,0.62)	0.800	−0.03 (−0.80, 0.73)	0.931	−0.41 (−0.90, 0.09)	0.110
Mean IOP, per 1mmHg higher	0.06 (−0.08, 0.20)	0.375	−0.05 (−0.14, 0.04)	0.283	0.05 (−0.04, 0.14)	0.285
MD, per 1dB better	0.16 (−0.14, 0.47)	0.289	0.15 (−0.03, 0.34)	0.116	0.06 (0.00,0.12)	0.037
Overall QI, per 1 unit higher	0.05 (−0.37, 0.47)	0.812	0.12 (−0.21,0.45)	0.472	0.26 (0.05, 0.47)	0.017

POAG = primary open angle glaucoma; GCC = ganglion cell complex; CI = confidence interval; IOP = intraocular pressure; MD = mean deviation; dB = decibels; QI = quality index.

Values with statistical significance are shown in bold.