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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Biotechnol Bioeng. 2020 May 29;117(8):2305–2318. doi: 10.1002/bit.27364

Table 2.

Selected non-conventional microbial hosts and cell-free systems for next generation bioprocessing

Bacteria Desirable phenotype
 Halomonas campaniensis  Thermo-, osmo-, and alkaline tolerance
 Clostridium thermocellum  Thermotolerance; lignocellulosic biomass breakdown
 Clostridium spec.  Use of CO / CO2 as sole carbon sources
 Methanotrophs  Use of gaseous alkanes as sole carbon sources
 Pseudomonas putida  Solvent tolerant; catabolism of aromatics
 Acidothiobacillus ferrooxidans  Acid tolerant; extracellular electron transfer
 Shewanella oneidensis  Extracellular electron transfer
Yeast and Fungi
 Kluyveromyces marxianus  Acid and thermotolerance; rapid growth
 Issatchenkia orientalis  Acid and thermotolerance
 Yarrowia lipolytica  Lipid catabolism
 Pichia pastoris  Heterologous protein expression
 Neocallimastigomycota  Lignocellulosic biomass breakdown
Cell-free systems
 Platforms  High-yielding, cost-effective, scalable bacterial systems for probing cellular function and biomanufacturing (E. coli, Vibrio natriegens, Streptomyces sp., clostridia, CHO, yeast, pichia pastoris, plants )