Table 1.
Transcription factors with binding sites enriched in the promoters of genes up- or down-regulated with age
| Gene symbol | P value, adjusted* | Odds ratio | No. of targets |
| Potential regulators up-regulated with age in liver | |||
| Spib | 9.17E-03 | 3.29 | 19 |
| Rela | 1.25E-02 | 1.57 | 109 |
| Mafb | 4.96E-02 | 1.84 | 42 |
| Potential regulators up-regulated with age in kidney | |||
| Irf3 | 1.87E-06 | 2.43 | 66 |
| Msx1 | 4.67E-04 | 1.43 | 261 |
| Rela | 7.64E-04 | 1.44 | 217 |
| Spib | 1.97E-02 | 2.29 | 28 |
| Ppara | 2.34E-02 | 1.49 | 101 |
| Cebpa | 4.41E-02 | 1.27 | 254 |
| Foxa3 | 4.41E-02 | 1.86 | 36 |
| Jarid2 | 4.41E-02 | 1.23 | 535 |
| Stat5a | 4.64E-02 | 1.30 | 194 |
| Potential regulators down-regulated with age in kidney | |||
| Hnf4a | 1.55E-02 | 1.45 | 156 |
| Arid1a | 1.55E-02 | 1.35 | 244 |
| Interactions of two transcription factors | |||
| Potential regulators up-regulated with age in kidney | |||
| Rela + Jun | 1.10E-02 | 1.82 | 55 |
| Ppara + Rxra | 3.08E-02 | 1.56 | 77 |
| Ppara + Gata4 | 3.08E-02 | 2.93 | 16 |
| Msx1 + Tbp | 3.20E-02 | 1.92 | 35 |
| Jun + Smad3 | 3.20E-02 | 1.71 | 49 |
| Stat5a + Esr1 | 3.20E-02 | 1.50 | 83 |
*
P values of right-sided Fisher’s exact test were adjusted with the Benjamini–Hochberg correction.