Table 1.
Formulation of Methotrexate-Loaded NLCs by 32Factorial Design: Factors, Their Levels and Transformed Values, Response: MPS and EE
| Batch No. | Compritol 888 (mg) |
Capmul MCM (mg) |
X1 | X2 | X11 | X22 | X1X2 | MPS ± SD* (nm) |
EE ± SD* (%) |
|---|---|---|---|---|---|---|---|---|---|
| A1 | 60 | 20 | −1 | −1 | 1 | 1 | 1 | 240± 15.9 | 42 ± 0.86 |
| A2 | 60 | 30 | −1 | 0 | 1 | 0 | 0 | 222± 15.02 | 44 ± 1.25 |
| A3 | 60 | 40 | −1 | 1 | 1 | 1 | −1 | 175 ± 20.1 | 34 ± 1.44 |
| A4 | 80 | 20 | 0 | −1 | 0 | 1 | 0 | 258 ± 12.2 | 44 ± 1.62 |
| A5 | 80 | 30 | 0 | 0 | 0 | 0 | 0 | 228± 14.5 | 53 ± 1.04 |
| A6 | 80 | 40 | 0 | 1 | 0 | 1 | 0 | 199 ± 20.44 | 44 ± 1.16 |
| A7 | 100 | 20 | 1 | −1 | 1 | 1 | −1 | 269 ± 10.28 | 47 ± 0.66 |
| A8 | 100 | 30 | 1 | 0 | 1 | 0 | 0 | 253 ± 8.65 | 54 ± 1.49 |
| A9 | 100 | 40 | 1 | 1 | 1 | 1 | 1 | 223 ± 12.32 | 46 ± 1.66 |
Note: *Data are represented as mean ± SD (n=3).