Table 2. Summary of myelin oligodendrocyte glycoprotein-antibody-positive patients.
| Patient number | Onset age, years | Sex | Clinical diagnosis | Number of demye-lination events | Disease course | Maintenance therapy regimen (number of events)* | Outcome (EDSS score) |
|---|---|---|---|---|---|---|---|
| 1 | 14 | Male | Recurrent ON | 6 | Unilateral ON (left)×5 → Unilateral ON (right) | Mycophenolic acid (5) | 0 |
| 2 | 13 | Female | Unclassified | 5 | Brain demyelination×5 | Interferon (2) | 0 |
| Azathioprine (4) | |||||||
| 3 | 5.6 | Male | MS | 4 | Brain demyelination×4 | Azathioprine, glucocorticoid (3) | 0 |
| Mycophenolic acid (4) | |||||||
| 4 | 2.8 | Male | MS | 3 | Brain demyelination×2 → brain | Interferon (2) | 0 |
| 5 | 11.2 | Female | MS | 3 | Brain demyelination×3 | Glucocorticoid (3) | 0 |
| 6 | 12.3 | Female | Unclassified | 3 | Brain demyelination×3 | Azathioprine (2) | 2 |
| 7 | 7.3 | Female | MS | 3 | Brain demyelination×3 | Glucocorticoid (2) | 0 |
| 8 | 16.6 | Female | Unclassified | 2 | Brain demyelination → brain demyelination+myelitis (long) | Azathioprine (1) | 0 |
| 9 | 3.3 | Female | NMOSD | 3 | Bilateral ON → brain demyelination+myelitis (long) → brain demyelination | Azathioprine (3) | 0 |
| 10 | 10.1 | Female | Unclassified | 3 | Bilateral ON → brain demyelination×2 | None | 0 |
| 11 | 9.4 | Male | MS | 2 | Brain demyelination(e) → brain demyelination | Interferon (2) | 0 |
| 12 | 5.3 | Female | Unclassified | 2 | Brain demyelination(e) → ON | None | 0 |
| 13 | 6.7 | Female | Unclassified | 2 | Bilateral ON+brain demyelination → brain demyelination(e) | Glucocorticoid (2) | 0 |
| 14 | 11.6 | Female | ADEM | 1 | Brain demyelination(e) | None | 0 |
| 15 | 9.3 | Male | Unclassified | 2 | Bilateral ON+brain demyelination → bilateral ON | None | 0 |
| 16 | 7.9 | Male | NMOSD | 2 | Brain demyelination+myelitis (long) → unilateral ON (right) | Azathioprine, glucocorticoid (2) | 0 |
| 17 | 6.5 | Female | NMOSD | 2 | Brain demyelination+bilateral ON → myelitis (long)+bilateral ON+brain demyelination | Glucocorticoid (1) | 0 |
| Mycophenolic acid (2) | |||||||
| 18 | 10 | Female | NMOSD | 2 | Myelitis (long) → unilateral ON (right)+brain demyelination | Azathioprine, glucocorticoid (2) | 0 |
| 19 | 5.4 | Female | NMOSD | 2 | Brain demyelination+myelitis (long) → brain demyelination+unilateral ON (right) | None | 0 |
| 20 | 4.7 | Male | ADEM | 1 | Brain demyelination(e) | None | 0 |
| 21 | 4.2 | Male | ADEM | 1 | Brain demyelination(e)+myelitis (short) | None | 0 |
| 22 | 6.1 | Male | ADEM | 1 | Brain demyelination(e)+myelitis (long) | None | 0 |
| 23 | 6.1 | Male | ADEM | 1 | ADEM | None | 0 |
| 24 | 5.7 | Male | ADEM | 1 | Brain demyelination(e) | None | 0 |
| 25 | 11.6 | Male | ADEM | 1 | Brain demyelination(e) | None | 0 |
| 26 | 2.4 | Male | ADEM | 1 | Brain demyelination(e) | None | 4 |
| 27 | 3.7 | Male | ADEM | 1 | Brain demyelination(e) | None | 0 |
| 28 | 4.9 | Male | ADEM | 1 | Brain demyelination(e)+myelitis (short)+bilateral ON | None | 0 |
| 29 | 1.3 | Male | ADEM | 1 | Brain demyelination(e)+myelitis (long) | None | 0 |
| 30 | 1.9 | Female | ADEM | 1 | Brain demyelination(e) | None | 0 |
| 31 | 6.6 | Female | ADEM | 1 | Brain demyelination(e) | None | 0 |
| 32 | 5.3 | Female | ADEM | 1 | Brain demyelination(e)+myelitis (long) | None | 1 |
| 33 | 4.3 | Female | ADEM | 1 | Brain demyelination(e) | None | 0 |
| 34 | 5.7 | Female | ADEM | 1 | Brain demyelination(e)+myelitis (long) | None | 0 |
| 35 | 3.3 | Female | ADEM | 1 | Brain demyelination(e) | None | 2 |
| 36 | 10.8 | Male | Other CIS | 1 | Brain demyelination+myelitis (long) | None | 0 |
| 37 | 17.4 | Male | Other CIS | 1 | Brain demyelination | None | 0 |
| 38 | 14.9 | Male | ON | 1 | Unilateral ON (left) | None | 0 |
| 39 | 5.4 | Male | ON | 1 | Unilateral ON (left) | None | 0 |
| 40 | 13.8 | Female | Other CIS | 1 | Brain demyelination+bilateral ON | None | 0 |
| 41 | 6.4 | Female | ON | 1 | Bilateral ON | None | 0 |
| 42 | 9.0 | Female | Other CIS | 1 | Brain demyelination | None | 0 |
| 43 | 6.1 | Female | ON | 1 | Bilateral ON | None | 0 |
| 44 | 10.5 | Female | ON | 1 | Bilateral ON | None | 0 |
| 45 | 9.0 | Female | NMOSD | 1 | Unilateral ON+myelitis (long) → brain demyelination (subclinical) | None | 0 |
| 46 | 5.3 | Male | ON | 1 | Unilateral ON | None | 0 |
| 47 | 1.7 | Male | Encephalitis | 0 | Encephalitis | 0 | |
| 48 | 11.8 | Male | Encephalitis | 0 | Encephalitis → epilepsy | 0 |
*The timing of starting after the (nth) attack.
ADEM: acute disseminated encephalomyelitis, EDSS: Expanded Disability Status Scale, MS: multiple sclerosis, NMOSD: neuromyelitis optica spectrum disorder, ON: optic neuritis, Other CIS: clinically isolated syndrome other than isolated ON or isolated transverse myelitis, (e): with encephalopathy, (long): at least three vertebral segments, (short): fewer than three vertebral segments.