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. 2020 Jul 13;11(7):525. doi: 10.1038/s41419-020-2683-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a IC50 of A549, H1975, A549/GR, and H1975/GR was detected. b qRT-PCR was conducted to investigate the expression of signaling pathway receptors (NOTCH-1, NOTCH-2, NOTCH-3, and NOTCH-4) and ligands (Jagged-1, Jagged-2, and Delta-1) in human lung adenocarcinoma cells (A549 and H1975) and their relevant drug-resistant cell lines (A549/GR and H1975/GR). c The protein level of NOTCH-1was tested via western blot. d The alteration of SNHG15 expression caused by sh-NOTCH-1 was tested in A549/GR and H1975/GR via qRT-PCR. e qRT-PCR was used to test the interference efficiency of SNHG15. f–i The proliferation, apoptosis, and cell cycle of A549/GR and H1975/GR were investigated by colony formation assay, EdU assay and flow cytometry analysis. Data obtained from three replications were shown as mean ± S.D. *P < 0.05, **P < 0.01 indicated that differences were statistically significant.