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. 2020 Jul 13;11(7):523. doi: 10.1038/s41419-020-2734-3

Fig. 7. Skin repair and neural function recovery in NTD fetuses after BMSC transplantation.

Fig. 7

a Representative images of E20 rat fetuses with spina bifida aperta after BMSC transplantation taken using fluorescent stereomicroscopy (top) and in vivo imaging (bottom). The lumbosacral region (arrowhead) is enlarged in the inset. b Untreated spina bifida aperta fetuses on E20 were examined by stereomicroscopy and in vivo imaging. The arrowhead indicates the unclosed lumbosacral spinal cord and skin. The presence of skeletal defects at the lumbosacral regions were shown by X-ray imaging. c Stereomicroscopic (top) and X-ray images of a normal rat fetus. d Quantitative analysis of the skin lesion area comparing the BMSC-injected (n = 30) and PBS-injected groups (n = 23). * P < 0.05 compare to PBS-injected group, Student′s t-test. e The operation schematic diagram of MEPs experiments on rat fetuses. f–h Representative MEP waveforms collected by a multi-channel electrophysiology recorder from a normal fetus (f), a fetus with spina bifida aperta (g), and a fetus with spina bifida aperta that received transplanted BMSCs (h). i Analysis of MEP latency and amplitude in the normal controls (n = 10), PBS-injected group (n = 12) and BMSC-injected group (n = 12). *Significant difference compare to the normal controls, †Significant difference compare to the PBS-injected group, P < 0.05. Scale bars: 2.5 mm.