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. 2020 Jun 24;117(27):15977–15988. doi: 10.1073/pnas.1919313117

Fig. 6.

Fig. 6.

Combi-antimiR suppresses seizures in established epilepsy. (A) Relative levels of miRNAs measured 24 h after injection of combi-antimiR, confirming effective inhibition of all three targeted miRNAs (closed circles, male mice; open circles, female mice, pooled for statistics; all t test *P < 0.05, **P < 0.01; n = 5 mice [scramble] and 6 mice [combi-antimiR]). (B) Representative EEGs during SE induced by IAKA in mice pretreated 24 h previously with scramble or combi-antimiR (#, EEG artifacts [excluded from analysis]). (C) Scatterplot showing total EEG power during SE for all mice pretreated with combi-antimiR (closed circles, male mice; open circles, female mice, pooled for statistics; t test ****P < 0.0001, n = 11 mice per group). (D) Representative EEGs showing typical spontaneous recurrent seizure (SRS) in epileptic mice posttreated 2 wk after SE with either scramble or combi-antimiR. (E) Scatterplots show posttreatment of epileptic mice with combi-antimiR reduced EEG power during ictal periods and the number of SRS per hour averaged during the recording period compared to scramble (all t test, α-corrected to 0.025 for multiple testing, ictal power posttreatment P = 0.0061, number of SRS posttreatment, P = 0.011).