Fig. 3.

Complete loss of POLR3G in mice is early embryonic lethal. (A) Summary of viability data indicating that Polr3g^fn/fn embryos died between E3.5 and E6.5. (B) An example of a Polr3g^fn/fn embryo, compared to a control embryo, arrested at the beginning of the blastula stage. (C) Summary of data indicating that a 50% reduction of POLR3GL in Polr3g^fn/fn embryos results in an enhanced arrest (from 36 to 89%) of embryonic development at the early blastula stage.